Title | Cohort selection and the estimation of racial disparity in mortality of extremely preterm neonates |
Publication Type | Web Article |
Year of Publication | 2023 |
Authors | Gould JB, Bennett MV, Profit J, Lee HC |
Publisher | Pediatric Research |
Abstract | Background Racial disparities in preterm neonatal mortality are long-standing. We aimed to assess how cohort selection influences mortality rates and racial disparity estimates. Methods With 2014–2018 California data, we compared neonatal mortality rates among Black and non-Hispanic White very low birth weight (VLBW, <1500 g) or very preterm infants (22–29 weeks gestational age). Relative risks were estimated by different cohort selection criteria. Blinder-Oaxaca decomposition quantified factors contributing to mortality differential. Results Depending upon standard selection criteria, mortality ranged from 6.2% (VLBW infants excluding first 12-h deaths) to 16.0% (22–29 weeks’ gestation including all deaths). Black observed neonatal mortality was higher than White infants only for delivery room deaths in VLBW infants (5.6 vs 4.2%). With risk adjustment accounting for higher rate of low gestational age, low Apgar score and other factors, White infant mortality increased from 15.9 to 16.6%, while Black infant mortality decreased from 16.7 to 13.7% in the 22–29 weeks cohort. Across varying cohort selection, risk adjusted survival advantage among Black infants ranged from 0.70 (CL 0.61–0.80) to 0.84 (CL 0.76–0.93). Conclusions Standard cohort selection can give markedly different mortality estimates. It is necessary to reduce prematurity rates and perinatal morbidity to improve outcomes for Black infants. Impact
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URL | https://www.nature.com/articles/s41390-023-02766-0#citeas |
DOI | 10.1038/s41390-023-02766-0 |