Cognitive outcomes after neonatal encephalopathy.

Authors:

A. Pappas; S. Shankaran; S.A. McDonald; B.R. Vohr; S.R. Hintz; R.A. Ehrenkranz; J.E. Tyson; K. Yolton; A. Das; R. Bara; J. Hammond; R.D. Higgins; Hypothermia Extended Follow-up Subcommittee of the Eunice Kennedy Shriver NICHD Neonatal Research Network

Abstract:

OBJECTIVES: To describe the spectrum of cognitive outcomes of children with and without cerebral palsy (CP) after neonatal encephalopathy, evaluate the prognostic value of early developmental testing and report on school services and additional therapies.

METHODS: The participants of this study are the school-aged survivors of the National Institute of Child Health and Human Development Neonatal Research Network randomized controlled trial of whole-body hypothermia. Children underwent neurologic examinations and neurodevelopmental and cognitive testing with the Bayley Scales of Infant Development-II at 18 to 22 months and the Wechsler intelligence scales and the Neuropsychological Assessment-Developmental Neuropsychological Assessment at 6 to 7 years. Parents were interviewed about functional status and receipt of school and support services. We explored predictors of cognitive outcome by using multiple regression models.

RESULTS: Subnormal IQ scores were identified in more than a quarter of the children: 96% of survivors with CP had an IQ

Citation:

Pappas A, Shankaran S, McDonald SA, et al. "Cognitive outcomes after neonatal encephalopathy." Pediatrics. 2015;135(3):e624-34.PubMed

Publication type:

Journal Article

Year:

2015

CPQCC publication:

Yes

PubMed ID:

25713280

PMCID:

PMC4338321