Cortisol awakening response and developmental outcomes at 6-7 years in children born extremely preterm.

Authors:

J. Lowe; J.F. Fuller; A.G. Dempsey; B. Do; C.M. Bann; A. Das; K.E. Gustafson; B.R. Vohr; S.R. Hintz; K.L. Watterberg; SUPPORT NEURO School-Age Study Subcommittee of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

Abstract:

BACKGROUND: Extremely preterm (EPT) birth has been related to dysregulation of stress responses and behavioral/learning problems at school age. Early adverse experiences can blunt HPA axis reactivity. We hypothesized that an attenuated cortisol awakening response would be associated with developmental and behavioral problems at school age in EPT children.

METHODS: This secondary analysis of a sub-cohort of the SUPPORT study included children born between 24 and 27 weeks, evaluated at 6-7 years with a neurodevelopmental battery and cortisol measures. Differences were tested between EPT and a term-born group. Relationships of cortisol awakening response to test scores were analyzed.

RESULTS: Cortisol was measured in 110 EPT and 29 term-born 6-7 year olds. Unadjusted WISC-IV and NEPSY-II scores were significantly worse among EPT children only. Conners Parent Rating Scale behavior scores were significantly worse among EPT children. After adjusting for covariates, blunted cortisol awakening responses were found to be associated with poorer scores on memory tests and greater problems with inattention for the EPT group (p

Citation:

Lowe J, Fuller JF, Dempsey AG, et al. "Cortisol awakening response and developmental outcomes at 6-7 years in children born extremely preterm." Pediatr Res. 2022.PubMed

Publication type:

Journal Article

Year:

2022

CPQCC publication:

Yes

PubMed ID:

35715492