Is phototherapy exposure associated with better or worse outcomes in 501- to 1000-g-birth-weight infants?

Authors:

S.R. Hintz; D.K. Stevenson; Q. Yao; R.J. Wong; A. Das; K.P. Van Meurs; B.H. Morris; J.E. Tyson; W. Oh; K. Poole; D.L. Phelps; G.E. McDavid; C. Grisby; R.D. Higgins; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

Abstract:

AIM: To compare risk-adjusted outcomes at 18- to 22-month-corrected age for extremely low birth weight (ELBW) infants who never received phototherapy (NoPTx) to those who received any phototherapy (PTx) in the NICHD Neonatal Research Network randomized trial of Aggressive vs. Conservative Phototherapy.

METHODS: Outcomes at 18 to 22-month-corrected age included death, neurodevelopmental impairment (NDI) and Bayley Scales Mental Developmental Index (MDI). Regression models evaluated the independent association of PTx with adverse outcomes controlling for centre and other potentially confounding variables.

RESULTS: Of 1972 infants, 216 were NoPTx and 1756 were PTx. For the entire 501- to 1000-g-BW cohort, PTx was not independently associated with death or NDI (OR 0.85, 95% CI: 0.60-1.20), death or adverse neurodevelopmental endpoints. However, among infants 501-750 g BW, the rate of significant developmental impairment with MDI

Citation:

Hintz SR, Stevenson DK, Yao Q, et al. "Is phototherapy exposure associated with better or worse outcomes in 501- to 1000-g-birth-weight infants?" Acta Paediatr. 2011;100(7):960-5.PubMed

Publication type:

Journal Article

Year:

2011

CPQCC publication:

Yes

PubMed ID:

21272067

PMCID:

PMC3505994