The relationship of neurodevelopmental impairment to concurrent early childhood outcomes of extremely preterm infants.

Authors: 
M.A. Rysavy; T.T. Colaizy; C.M. Bann; S.B. DeMauro; A.F. Duncan; J.E. Brumbaugh; M. Peralta-Carcelen; H.M. Harmon; K.J. Johnson; S.R. Hintz; B.R. Vohr; E.F. Bell; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Abstract: 

OBJECTIVE: Determine how neurodevelopmental impairment (NDI) relates to concurrent outcomes for children born extremely preterm.

STUDY DESIGN: Retrospective cohort study children born 22 0/7-26 6/7 weeks' gestation at NICHD Neonatal Research Network hospitals. Outcomes were ascertained at 18-22 months' corrected age.

RESULT: Of 6562 children, 2618 (40%) died and 441 (7%) had no follow-up. Among the remaining 3483 children, 825 (24%), 1576 (45%), 657 (19%), and 425 (12%) had no, potential/mild, moderate, and severe NDI, respectively. Rehospitalization, respiratory medications, surgery, and medical support services were associated with greater NDI severity but affected >10% of children without NDI. Rehospitalization occurred in 40% of children with no NDI (mean (SD): 1.7 (1.3) episodes).

CONCLUSION: Medical, functional, and social outcomes at 18-22 months' corrected age were associated with NDI; however, many children without NDI were affected. These data should contribute to counseling families and the design of studies for childhood outcomes beyond NDI.

Citation: 

Rysavy MA, Colaizy TT, Bann CM, et al. "The relationship of neurodevelopmental impairment to concurrent early childhood outcomes of extremely preterm infants." J Perinatol. 2021;41(9):2270-2278.PubMed

Publication type: 
Journal Article
Year: 
2021
CPQCC publication: 
Yes
PubMed ID: 
33758389
PMCID: 
PMC7985590