Association between sedation-analgesia and neurodevelopment outcomes in neonatal hypoxic-ischemic encephalopathy.

Authors:

G. Natarajan; S. Shankaran; A.R. Laptook; S.A. McDonald; A. Pappas; S.R. Hintz; A. Das; NICHD Neonatal Research Network (NRN) Whole Body Hypothermia Subcommittee

Abstract:

OBJECTIVE: To evaluate the association between sedation-analgesia (SA) during initial 72 h and death/disability at 18 months of age in neonatal hypoxic-ischemic encephalopathy (HIE).

DESIGN: This was a secondary analysis of the NICHD therapeutic hypothermia (TH) randomized controlled trial in moderate or severe HIE. Receipt of SA and anticonvulsant medications at five time points were considered: prior to and at baseline, 24, 48, and 72 h of TH or normothermia. Disability was defined as mental developmental index

Citation:

Natarajan G, Shankaran S, Laptook AR, et al. "Association between sedation-analgesia and neurodevelopment outcomes in neonatal hypoxic-ischemic encephalopathy." J Perinatol. 2018;38(8):1060-1067.PubMed

Publication type:

Journal Article

Year:

2018

CPQCC publication:

Yes

PubMed ID:

29795315

PMCID:

PMC6092226